The SYVN1 antibody from Wuhan Fine Biotech Co., Ltd. is a Rabbit Polyclonal antibody to synoviolin 1. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The SYVN1 antibody has been validated for the following applications: EIA, Immunoassay, Precipitation, ELISA, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control(ERQC) system also called ER-associated degradation(ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin(HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis